Treatment with levodopa and risk for malignant melanoma
Identifieur interne : 000F20 ( Main/Exploration ); précédent : 000F19; suivant : 000F21Treatment with levodopa and risk for malignant melanoma
Auteurs : J Rgen H. Olsen [Danemark] ; Karina Tangerud [Danemark] ; Lene Wermuth [Danemark] ; Kirsten Frederiksen [Danemark] ; S Ren Friis [Danemark]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-15.
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Abstract
A large follow‐up study in Denmark of 14,088 patients in whom Parkinson's disease was diagnosed at hospital showed a twofold higher incidence of malignant melanoma in these patients than in the general population. In a nested case–control study of 45 patients with malignant melanoma, 97 patients with nonmelanoma skin cancer, and 172 control subjects, we investigated the hypothesis that treatment with levodopa increases the risk for skin cancer. Information on diagnoses and treatment was retrieved from medical records. We observed a significant fourfold to fivefold increase in the risk for malignant melanoma in a subgroup of patients with a probable diagnosis of idiopathic Parkinson's disease as compared with other patients. There was apparently no effect of levodopa on the risk for malignant melanoma as indicated by an odds ratio of 1.0 (95% confidence interval, 0.8–1.3) per 1,000 g cumulative intake of the drug. We conclude that the increased rate of malignant melanoma observed in patients treated at hospital for Parkinson's disease is restricted to those with idiopathic Parkinson's disease, however, unrelated to the treatment with levodopa. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21397
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-15">2007-07-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1252">1252</biblScope><biblScope unit="page" to="1257">1257</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D12E7854CF05320F03B3DC7AA5FC409DF67669C8</idno><idno type="DOI">10.1002/mds.21397</idno><idno type="ArticleID">MDS21397</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>levodopa treatment</term><term>malignant melanoma</term><term>nonmelanoma skin cancer</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A large follow‐up study in Denmark of 14,088 patients in whom Parkinson's disease was diagnosed at hospital showed a twofold higher incidence of malignant melanoma in these patients than in the general population. In a nested case–control study of 45 patients with malignant melanoma, 97 patients with nonmelanoma skin cancer, and 172 control subjects, we investigated the hypothesis that treatment with levodopa increases the risk for skin cancer. Information on diagnoses and treatment was retrieved from medical records. We observed a significant fourfold to fivefold increase in the risk for malignant melanoma in a subgroup of patients with a probable diagnosis of idiopathic Parkinson's disease as compared with other patients. There was apparently no effect of levodopa on the risk for malignant melanoma as indicated by an odds ratio of 1.0 (95% confidence interval, 0.8–1.3) per 1,000 g cumulative intake of the drug. We conclude that the increased rate of malignant melanoma observed in patients treated at hospital for Parkinson's disease is restricted to those with idiopathic Parkinson's disease, however, unrelated to the treatment with levodopa. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Olsen, J Rgen H" sort="Olsen, J Rgen H" uniqKey="Olsen J" first="J Rgen H." last="Olsen">J Rgen H. Olsen</name></region><name sortKey="Frederiksen, Kirsten" sort="Frederiksen, Kirsten" uniqKey="Frederiksen K" first="Kirsten" last="Frederiksen">Kirsten Frederiksen</name><name sortKey="Friis, S Ren" sort="Friis, S Ren" uniqKey="Friis S" first="S Ren" last="Friis">S Ren Friis</name><name sortKey="Tangerud, Karina" sort="Tangerud, Karina" uniqKey="Tangerud K" first="Karina" last="Tangerud">Karina Tangerud</name><name sortKey="Wermuth, Lene" sort="Wermuth, Lene" uniqKey="Wermuth L" first="Lene" last="Wermuth">Lene Wermuth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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